DTCS draws from knowledge accumulated from nearly four decades of industrial experience of conducting innovative Chemical Process Research and Development studies in the chemical industry. This experience is the basis for DTCS success and comes from scaling up more than 100 different complex chemical processes directly from laboratory bench-scale data to production plant equipment. Information obtained from bench-scale research was used to prepare specialty chemicals for government and commercial applications in batch and continuous flow equipment ranging from 30 to 2000 gallons in vessel capacity. Some of these chemical processes developed at the bench and scaled to production plant equipment are listed below:

Commercial Chemical List

• A process improvement for the efficient recovery of phosphine, mono-, di- and trialkylphosphines from process streams.
• A continuous flow nitration process for a polynitro aromatic herbicide.  This process was safely used to prepare several million pounds of product over a three-year period and proved to be superior to the hazardous batch process originally used for its manufacture. 
• A two-step reaction using a combined batch/continuous process to manufacture ethylenimine, a highly toxic and carcinogenic chemical.  This process had a scale-up ratio of laboratory to plant equipment of 1 to 20,000. 
• A number of batch and continuous processes to manufacture ethylenimine derivatives including N-hydroxyethyl ethylenimine; 2-aziridinyl-1-phenylethanol; methyl-2-aziridinyl butyrate; 3-aziridinyl butyronitrile; iminol methacrylate and a number of polyethylenimines. 
• A continuous process to manufacture 2,2-dimethyl-thiazolidine, an intermediate in the preparation of cysteamine hydrochloride, used in the formulation of an anti-ulcer drug, Tagamet (Cimetidine).     
• A two-step process to prepare 10,10'-oxy-bisphenoxarsine, an arsenical used as a microcide in a number of commercial applications.  Because of the toxic nature of the process, a thorough understanding of waste management was a critical part of the success of this program.
• A four-step process to prepare an X-ray opaque plasticizer, 2-(2-methoxyethoxy)-ethyl-2, 5-diiodobenzoate.

Defense Related Chemical List:

• A safe method to prepare sodium dinitroethane, an intermediate in the preparation of bis(2,2-dintropropyl)acetal and –formal (BDNPA/F).  This process improvement eliminated the incidence of explosions that were experienced in the previous process.  Later, directed efforts resulted in the identification of impurities formed in the production of BDNPA/F and then defined the process control criteria necessary to eliminate, or minimize, these impurities from the final product.  The results of this effort have significantly increased the shelf-life of BDNPA/F.
• A two-step batch process for the preparation of TATB (sym-triaminotrinitro-benzene) from s-trichloro-benzene. 
• A continuous process using elemental fluorine to prepare fluorotrinitromethane.  Production processes were also developed to convert this material into 2-fluoro-2, 2-dinitroethanol and bis(2-fluoro-2, 2-dinitroethyl)formal (FEFO).
• A process to prepare triaminoguanidinium nitrate (TAGN) starting from cyanamide. 
• A two-step oxidative nitration process to prepare 2,2-dinitropropanediol-1, 3. 
• A four-step process working with hazardous intermediates to prepare a polynitro formal (DINOL). 
• A semi-continuous process to prepare 1,1-dinitroethane.
• A one-step process to prepare ethyl 4,4- dinitropentanoate. 
• A two-step process to prepare 3,3-dinitropentane-1, 5-dicarboxylic acid. 

[ Home ]

Copyright © 2002 Dimension Technology Chemical Systems, Inc.